Coherent Identifier About this item: 20.500.12592/6tf2nr

Ferumoxytol versus other intravenous iron therapies for anemia




Anemia, particularly iron deficiency anemia, is a common complication in patients with end stage chronic kidney disease (CKD, stage disease and those on dialysis). CKD patients have a deficiency in endogenous erythropoietin (a hormone that stimulates the production of red blood cells) often requiring supplementation with erythropoiesis-stimulating agents (ESA), which results in increased utilization of iron, depleting iron stores. Additionally CKD patients have reduced iron intake, compromised gastrointestinal iron absorption and bleeding (including blood loss during the dialysis process). Evidence suggests that intravenous (IV) iron is preferred to oral for patients receiving ESA therapy and undergoing dialysis. For non-dialysis patients there is insufficient evidence to suggest the preferential use of IV formulations, therefore oral therapy should be tried first and IV iron used if there is an inadequate response or the patient cannot tolerate oral therapy. Ferumoxytol (Feraheme) is an intravenous iron formulation available in Canada for the treatment of iron deficiency anemia (IDA) in adults with CKD. This report will review the comparative efficacy, safety and cost-effectiveness data of ferumoxytol relative to the alternative IV iron preparations available in Canada. It will also review evidence based guidelines for the use of ferumoxytol.


health cost-benefit analysis research systematic reviews chemicals iron medical research medicine health care therapy erythropoietin clinical trial anemia, iron-deficiency clinical medicine iron compounds evidence-based healthcare policy health treatment health sciences government health care medical specialties pharmaceutical chronic kidney disease erythropoiesis red blood cells iron supplement iron therapies ferumoxytol intravenous iron iron deficiency anemia

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Includes bibliographical references (p. 7-8)
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7 June 2013
Issued as part of the desLibris documents collection
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F478 2013eb
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1 electronic text (11 p.)
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Mode of access: World Wide Web
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