For occupational health practitioners and the research community, knowledge of the exposure of workers occurring both in the past and present is important in monitoring the health of workers. [...] Occupational exposure assessment by experts The methodology of occupational exposure assessment by experts in the context of community-based case-control studies was first developed by Siemiatycki and Gérin in the context of the MCS. [...] The rating of confidence was subjective and relied on the level of detail provided by the respondent, and on the expert’s opinion of the credibility of the interview, the amount of documentary evidence that the experts could find in the international literature on exposures in such a job, and the availability of local information concerning such jobs. [...] At each of these levels (j = 1, 2, 3, 4), the logit of the probability of exposure logit(pjk) was given a normal conditional prior distribution with the mean equal to the logit of the probability of exposure at the preceding level - logit(p(j-1,k)) - and a distinct standard deviation Σj. [...] With the exception of the lowest category, for which the minimum notable difference was selected a priori by the research team, the notable difference for the remaining categories was selected to be a quarter of the upper limit of the range of values (e.g.
Authors
- Pages
- 163
- Published in
- Canada
Table of Contents
- R-1190-en 1
- INTRODUCTION 17
- 1. RESEARCH OBJECTIVES 24
- 2. METHODOLOGY 25
- 2.1 Objective 1: Expert assessment of occupational exposures 25
- 2.1.1 The Montréal Breast Cancer Case-Control Study 25
- 2.1.2 Attribution of occupational codes and exposure assessment 25
- 2.2 Objective 2: Incorporation of the new expert assessments into CANJEM 27
- 2.2.1 Objective 2a. Descriptive comparison of sex-specific estimation of CANJEM exposure metrics 29
- 2.2.2 Objective 2b. Bayesian comparison of sex-specific estimation of the probability of exposure metric in CANJEM 31
- 2.3 Objective 3: Estimation of prevalent occupational exposures among Montréal women 33
- 3. RESULTS 35
- 3.1 Inter-rater reliability of expert assessment of occupational exposures 35
- 3.2 Incorporation of the new expert evaluations into CANJEM 35
- 3.2.1 Descriptive comparison of sex-specific estimation of CANJEM exposure metrics 35
- 3.2.2 Bayesian comparison of sex-specific estimation of exposure metrics in CANJEM 44
- 3.3 Estimation of prevalent occupational exposures among Montréal women 52
- 4. DISCUSSION 61
- 4.1 Occupations 61
- 4.2 Prevalent exposures 62
- 4.3 Notable differences in exposures by occupational group 63
- 4.4 Strengths and limitations 65
- CONCLUSION 68
- REFERENCES 69
- APPENDIX A Illustration of CANJEM dimensions and of its list of agents 75
- APPENDIX B Main Analysis: Empirical Cumulative Density Function (ECDF) plots 81
- APPENDIX C Sensitivity analyses 82
- APPENDIX D Comparison of exposures between sex-specific JEMs 98
- APPENDIX E Notable differences across agent-occupation combinations between sexes 104
- APPENDIX F Bayesian comparison of sex-specific estimation of exposure metrics 114
- APPENDIX G Comparison of most notable differences greater in women or in men when modifying time period 143
- APPENDIX H Exposure metrics of agents with probability of exposure ≥ 5% among Montreal women 155
