Several water-soluble compounds can be used in oral hygiene products, but the zinc compounds generally used in oral hygiene products include zinc acetate (Zn2+- proportion: 35.64 %), zinc chloride (Zn2+- proportion: 47.98 %), zinc gluconate (Zn2+- proportion: 13.29 %), zinc citrate (Zn2+- proportion: 22.77 %), zinc sulphate (Zn2+- proportion: 40.50 % / 22.74 %). Since water-soluble zinc salts are ionically bonded compounds consisting of cationic zinc and acid residue anion(s), dissolution of these salts in aqueous media causes dissociation by creating solvated zinc cations and respective anion(s). In the dissolved state, zinc and anions are no longer ionically bound but interact independently with water molecules instead. As a consequence, they exert their biological activity independent from each other under physiological conditions. However, while the anions may possess different biological activities of their own at different concentrations, it is the effects that are driven by zinc that all water soluble zinc salts have in common.
Authors
Directorate-General for Health and Food Safety, European Commission
- Catalogue number
- EW-AQ-24-011-EN-N
- Citation
- European Commission, Directorate-General for Health and Food Safety, Opinion on water-soluble zinc salts used in oral hygiene products – Submission II , Publications Office of the European Union, 2024, https://data.europa.eu/doi/10.2875/34727
- DOI
- https://data.europa.eu/doi/10.2875/34727
- ISBN
- 978-92-68-19394-5
- ISSN
- 1831-4767
- Pages
- 24
- Published in
- Belgium
- Themes
- Pharmaceutical and cosmetics industry , Consumers' health
Table of Contents
- OPINION ON 1
- - Submission II - 1
- In light of the data provided and taking under consideration the aggregate exposure including diet and the concerns on the Tolerable Daily Upper Intake 7
- 1. Does the SCCS consider that water soluble zinc salts are safe up to 1 as zinc in 7
- 2. Does the SCCS consider that the contribution of the cosmetic products among the 7
- 3.1 Chemical and Physical Specifications 8
- 3.2 Function and uses 8
- 3.3 Toxicological Evaluation 8
- 3.4 Toxicokinetics 11
- 3.5 Exposure assessment 12
- 3.6 Safety evaluation 15
- 7.01 16
- 9.40 16
- 11.56 16
- 10.94 16
- 12.28 16
- In light of the data provided and taking under consideration the aggregate exposure including diet and the concerns on the Tolerable Daily Upper Intake 20
- 1. Does the SCCS consider that water soluble zinc salts are safe up to 1 as zinc in 20
- 2. Does the SCCS consider that the contribution of the cosmetic products among the 20
