Skin Substitutes for Treating Chronic Wounds: Disposition of Comments

The responses to comments in this disposition report are those of the authors, who are responsible for its contents, and do not necessarily represent the views of the Agency for Healthcare Research and Quality. [...] We excluded any studies that used saline wet-to-dry gauze.” KI Reviewer #1 Introduction The major issue that both the authors and others have struggled Defining a skin substitute is beyond the scope of the technical with has been the definition of skin substitutes. [...] PAGE 3, Background Section, AHRQ made the Please note the disclaimer in the Front Matter of the report: #5: statement: “Although dermal substitutes can vary from skin “The findings and conclusions in this document are those of xenografts or allografts to a combination of autologous the authors, who are responsible for its contents; the findings keratinocytes over the dermal matrix, their common ob. [...] The Key Findings section and the Background section seem to minimize the importance of wound closure as the primary endpoint. [...] MPA Musculoskeletal Transplant Foundation Public Reviewer Methods Osiris agrees with most of the questions posed in the Risk of Bias Please note the disclaimer in the Front Matter of the report: #7: section.