cover image: Association between overweight, obesity, and quality of life of patients receiving an anticancer treatment for prostate cancer: a systematic literature review

Association between overweight, obesity, and quality of life of patients receiving an anticancer treatment for prostate cancer: a systematic literature review

1 Dec 2023

Abstract Background Prostate cancer (PCa) and obesity are two ever-increasing public health issues that can independently impair the quality of life (QOL) of affected patients. Our objective was to evaluate the impact of overweight and obesity on the QOL of patients with PCa receiving an anticancer treatment. Methods We performed a systematic review of the literature using PubMed, Embase, Cochrane Library and Web of Science databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The search equation targeted studies that included PCa patients who had a body mass index (BMI) greater than 25 kg/m 2 , who were receiving anticancer therapy, and whose QOL was analyzed according to validated or non-validated scores. Results Of 759 identified articles, we selected 20 studies published between 2000 and 2019 of 12,529 patients treated for PCa, including 5549 overweight or obese patients. QOL assessment was performed using nine validated scales and two non-validated questionnaires. Of seven studies on radiotherapy, six found obesity to have a negative impact on patients' QOL (especially urinary, sexual, and bowel-related QOL). Thirteen studies assessed the QOL of patients who underwent radical prostatectomy, with a BMI > 25 kg/m 2 having no observed impact. In obese patients under 65 years of age and without comorbidities, nerve-sparing surgery appeared to limit the deterioration of QOL. Four studies on brachytherapy found discordant results. One study showed greater QOL impairment in obese patients receiving first-generation hormone therapy than in those with normal or decreased BMI. No study evaluated the QOL of overweight or obese patients receiving other types of systemic treatment. Conclusion Based on the published data, the level of evidence for an association between QOL and overweight or obesity in patients treated for PCa is not high. Prospective cohort studies including this type of patient population are warranted to answer this topical public health issue.

Authors

Léonard Depotte, Maryline Caroux, Joseph Gligorov, Florence Canouï-Poitrine, Yazid Belkacemi, Alexandre de la Taille, Christophe Tournigand, Emmanuelle Kempf

Organizations mentioned

Bibliographic Reference
Léonard Depotte, Maryline Caroux, Joseph Gligorov, Florence Canouï-Poitrine, Yazid Belkacemi, et al.. Association between overweight, obesity, and quality of life of patients receiving an anticancer treatment for prostate cancer: a systematic literature review. Health and Quality of Life Outcomes, 2023, 21 (1), pp.11. ⟨10.1186/s12955-023-02093-2⟩. ⟨hal-03972057⟩
DOI
https://doi.org/10.1186/s12955-023-02093-2
HAL Collection
['Université Paris-Nord - Paris XIII', 'AP-HP', 'Institut Mondor de Recherche Biomédicale', 'Université Paris-Est Créteil Val-de-Marne', 'Centre de recherche Saint-Antoine - UMR S938', 'Sorbonne Université', "Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé", 'Université Sorbonne Paris Nord', 'Sorbonne Université 01/01/2018', 'Faculté de Santé de Sorbonne Université', 'Faculté des Sciences de Sorbonne Université', 'Médecine - Sorbonne Université', 'Sorbonne Université - Texte Intégral', 'Alliance Sorbonne Université']
HAL Identifier
3972057
Institution
['Institut National de la Santé et de la Recherche Médicale', 'CHU Tenon [AP-HP]', 'IFR10', 'Université Paris-Est Créteil Val-de-Marne - Paris 12', 'Hôpital Henri Mondor', 'CHU Henri Mondor [Créteil]', 'Université Sorbonne Paris Nord', 'Hôpital Albert Chenevier']
Laboratory
['Centre de Recherche Saint-Antoine', 'Institut Mondor de Recherche Biomédicale', "Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé", 'Groupe Henri Mondor-Albert Chenevier']
Published in
France

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