9 June 2021
Key Informants are not involved in the analysis of the evidence or the writing of the report. [...] • Studies evaluating WBRT as initial treatment addressed a variety of questions, including the use of radiosensitizers, the effect of neuroprotection, and the addition of systemic therapy. [...] Studies had to report on effects of radiation therapy in the 1990s or later and we included studies published to July 2020 at the time of the draft report. [...] The management of brain metastases is challenging due to the effects of the disease and treatment on patients. [...] Does the efficacy of WBRT depend on tumor histology and patient prognosis? What are the benefits and harms of WBRT on quality of life and neurocognition that need to be communicated to patients and caregivers? Do co-interventions such as memantine mitigate the neurocognitive effects, and if so, should they be offered in conjunction with WBRT? Is there a benefit to adding SRS to WBRT? And does the.