Harvard Kennedy School faculty member Jorrit de Jong and Harvard Business School Professor Amy Edmondson say the big, intractable problems challenges facing city leaders today are too complex to be addressed by any one agency or government department. Complex challenges like the shortage of economic opportunity and affordable housing, homelessness, the effects of the climate crisis, crime—and can only be solved by multiple organizations working together. But that’s easier said than done. Bringing together government agencies, nonprofits, private business, academia, and the public into successful collaborations can be a huge challenge. Different people bring different agendas and goals. They don’t necessarily trust each other. Sometimes they can’t even agree on what the problem actually is and they fail before even getting started. In a recent study, de Jong and Edmondson found that the most successful problem-solving collaborations have a number of things in common, including building a culture of safety and trust and being empowered to try, fail, and learn from mistakes. Sometimes, they say, the key can be just finding a place to start. Jorrit de Jong is the director of the Bloomberg Center for Cities at Harvard University and academic director of the Innovations in Government Program at the Ash Center for Democratic Governance and Innovation at HKS. Amy Edmondson is the Novartis Professor of Leadership and Management at the Harvard Business School, whose books and writings on teamwork in successful organizations have been translated into 15 languages.