This report presents the outcome from the JRC NUCLEAR FORESIGHT WORKSHOP on Shaping the Future for Nuclear Safety, Security and Safeguards - Factors, Forces and Challenges that was con-ducted on 24th November 2023 at the JRC-Karlsruhe in conjunction with “60 Years of JRC Nuclear Safety and Security”7. It built on the participation of representatives from EU Member States and international research, governmental and industrial organisations and from the EC, representing a large spectrum of stakeholders. The IAEA Drivers 2057 card deck presented at the IAEA Symposium on International Safeguards in 20226 inspired the foresight process used in this workshop. Five nu-clear and non-nuclear JRC portfolios jointly organised this pilot foresight initiative to reflect on the following 5 selected, non-exhaustive, Drivers 2057 of relevance to Europe: 1) Safety & Security, 2) Green, 3) Digital, 4) Dueal Use and 5) Fairness.\nThis report presents the purpose, process and organisation of this foresight workshop as a comple-mentary pilot initiative to the well-established Euratom Horizon Scanning3. For each Euratom Driver 2057, the report includes a series of considerations and recommendations stemming from the workshop discussions to address future scenarios and enablers but also challenges and potential disruptions. Participants further imagined the future role of the JRC and the adequate resources and competences to be better prepared towards 2057. \nThe report concludes with a reflection on the outcome and recommendations of the workshop with most recent developments of strategic importance for the European Union (EU). These insights can inspire further JRC’s research, science and policy support developments and facilitate to accommodate necessary strategic adjustment in response to the changing scientific and political landscape in the EU and at a global level.