Screening of aryl piperazine compounds Data to be shared by Katherine in next project in silico hemozoin adsorption model meeting Kiran mentioned that work at CDRI and JNU is stopped due to the pandemic and may resume by June. [...] Mode of action studies: MMV1803899 (phenyl amide), MMV1804508(cyclopropyl amide) and MMV1804317(aryl imidazole) were screened in the barcoded multiplex assay to understand the mechanism of resistance. [...] MMV1804317 will be screened in STPH cross Resistance panel and MMV1900786 will be screened in a Dd2 assay. [...] Since the parasitology (PRR and crossR) profile indicates that it may be a bc-1 inhibitor it will be sent to Akhil Vaidya, University of Drexel to profile in bc-1 assays. [...] Results of various modifications in aryl imidazole scaffold were discussed (slides 7-9) and it was agreed that central core rigidification will be prioritised for the next few months to evaluate the impact on Pf3D7 activity.
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