Notes of Malaria Libre 8project meeting - Discussion points: : - Action Item

metabolomics Screen more compounds from aryl imidazole 4 compounds were sent to TCGLS for screening scaffolds in Dd2 strain against Dd2 strain QSAR model of aryl imidazole to be fine-tuned Thiyaga based on the recommendations on slide 17 Project update was presented by Kiran and project members (Prem Prakash, Carlo, Shailja) presented the work done/ planned in their labs. [...] Key results discussed: pH fingerprinting data of exemplars from all the three scaffolds was discussed- none of the compounds have MoA that can be detected through this screen (slide 5) Carlo discussed about the trophozoite activity assay – there were comments about the experimental design and data interpretation and further deliberation is needed, so it was decided to discuss these in a follow up. [...] Designs based on the QSAR model will be taken up for discussion in the next project meetings. [...] Since modifications done in the different regions of the scaffold haven’t led to improved activity (<100nM) so far, Bob suggested that the team should do major modification in this series. [...] Jeremy mentioned that the profile of the molecule is very similar to atovaquone so it may be a bc-1 inhibitor.