Appendix 4. - Recommendations for Grading of Acute and Subacute Toxicity ALLERGY

TOXICITY SCALE (CTC-NCIC CRITERIA) Recommendations for Grading of Acute and Subacute Toxicity, Version Dec 1994 (revised) GRADE 0 1 2 3 4 GASTROINTESTINAL GI ANO Anorexia* none mild moderate severe dehydration GI APP none mild moderate - - Appetite increased* GI ASC Ascites none mild moderate severe life threatening (non malignant)* GI DIA Diarrhea none increase of 2 - 3 stools increase of 4 - 6 s. [...] req odynophagia* (incl recall reaction) GI DRY Mouth, none mild moderate severe - nose dryness* GI FIS Fistula* none - - req intervention req operation (intestinal, esophageal, rectal) GI GAS none mild moderate severe - Flatulence* GI HEA none mild moderate severe - Heartburn* (incl. [...] TOXICITY SCALE (CTC-NCIC CRITERIA) Recommendations for Grading of Acute and Subacute Toxicity, Version Dec 1994 (revised) GRADE 0 1 2 3 4 GU PRT no change 1 + 2 - 3 + 4 + nephrotic syndrome Proteinuria or < 0.3 g/% or 0.3 - 1.0 g/% or > 1.0 g/% or < 3 g/l or 3 - 10 g/l or > 10 g/l GU VAG Vaginitis* none mild, no trt req moderate, relieved with severe, not relieved life threatening (+/- vaginal trt. [...] Phos within normal limits ≤ 2.5 x N (Normal) 2.6 - 5.0 x N 5.1-20.0 x N > 20 x N or 5'nucleotidase (WNL) HP ALT WNL ≤ 2.5 x N (Normal) 2.6 - 5.0 x N 5.1-20.0 x N > 20 x N Transaminase SGPT (ALT) HP AST WNL ≤ 2.5 x N (Normal) 2.6 - 5.0 x N 5.1 - 20.0 x N > 20 x N Transaminase SGOT (AST) HP BIL Bilirubin WNL - < 1.5 x N 1.5 - 3.0 x N > 3.0 x N HP CLI Liver no change from - - precoma hepatic coma (cl. [...] changes pigmentation changes localized shallow or necrosis photosensitivity) or atrophy ulceration SK DES none dry desquamation moist desquamation confluent moist - Desquamation* desquamation SK DRY Dry skin* none mild moderate severe - SK FAC Flushing* none mild moderate severe - (eg:-facial) SK HEM none mild, no transfusion gross, 1 - 2 units gross, 3 - 4 units massive, > 4 units Bruising/bleedi.