Demand response is a short-term, voluntary decrease in electrical consumption by end-use customers that is generally triggered by compromised grid reliability or high wholesale market prices. In demand-response schemes, customers are remunerated for curtailing their loads (Federal Energy Management Program. n.d.). Curtailment can help balance energy supply and demand, ensure adequate capacity during times of stress on the system, and provide ancillary services such as frequency support and management of network congestion. The role of demand response in power markets is expected to grow significantly in the coming years. The case studies presented here prove that demand-response programs should be grounded in a country's context, targeting identified power system constraints. Demand-response mechanisms can be well targeted to specific objectives but are likely to be less effective if applied too broadly. As a first step in designing a demand-response program, a system diagnostic will identify the drivers of the need for demand response, which often include variable generation, network constraints, customer demand, and circumstances external to the system, such as a mandate for decarbonization. The driver's location is also essential: how it is dispersed geographically or over time, how immediate it is, and how it affects different customers. Finally, the structure of a country's power system and its experience with demand response will determine possible mechanisms and how they can be adopted. The benefits of demand response should be identified and evaluated through a cost-benefit analysis. The analysis should be based on a country's enabling conditions, market structure, and available (or soon-to-be-available) technologies. It should plot all demand response options (including do nothing) on a supply curve based on their net and distributed benefits, allowing them to be ranked in order of preference. After designing the mechanisms, enhancements to pertinent policy, legal, and regulatory frameworks should be accompanied by market education on their potential. Finally, the program should be implemented in accordance with a detailed roadmap and timeline, supported by pilot projects, quick wins, technical assistance for implementing institutions, and systematic monitoring and reviews.