Coherent Identifier About this item: 20.500.12592/gjs3vp

GB20 Pharmacopuncture As a Potential Method for Brain Drug Delivery via the Perivascular Spaces

11 May 2022

Summary

Background: The development of new methods of drug brain delivery is a crucial step for the effective therapy of the brain diseases. Pharma- and acupuncture are the forms of alternative therapy of the brain pathology, including an increase in the permeability of blood-brain barrier. However, the mechanisms of pharma- and acupuncture-mediated effects on the brain physiology remain not fully understood. Results: This pilot study on healthy mice clearly demonstrates the Evans Blue spreading in the mouse head and in the brain via the perivascular spaces (PVSs) of the trigeminal structure and the cribriform plate after the dye injection into the Feng Chi point (Galbladder 20, GB20). Conclusion: These results suggest that pharmacopuncture at GB20 can be a perspective method for brain drug delivery via PVSs.

Creators/Authors

Semyachkina-Glushkovskaya, Oxana
External Organizations

Blokhina, Inna
External Organizations

Navolokin, Nikita
External Organizations

Evsukova, Arina
External Organizations

Karandin, Georgy
External Organizations

Khorovodov, Alexander
External Organizations

Terskov, Andrey
External Organizations

Fedosov, Ivan
External Organizations

Dubrovsky, Alexander
External Organizations

Tzoy, Maria
External Organizations

Ageev, Vasily
External Organizations

Agranovich, Ilana
External Organizations

Telnova, Valeria
External Organizations

Tsven, Anna
External Organizations

Kurths, Jürgen
Potsdam Institute for Climate Impact Research

Tags

health nonlinear dynamics rd4 - complexity science

Citation
Semyachkina-Glushkovskaya, O., Blokhina, I., Navolokin, N., Evsukova, A., Karandin, G., Khorovodov, A., Terskov, A., Fedosov, I., Dubrovsky, A., Tzoy, M., Ageev, V., Agranovich, I., Telnova, V., Tsven, A., Kurths, J. (2022): GB20 Pharmacopuncture As a Potential Method for Brain Drug Delivery via the Perivascular Spaces. - Journal of Acupuncture and Meridian Studies, 15, 1, 43-49.
Rights Holder
http://creativecommons.org/licenses/bync/4.0/

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