Since 2021, the Partnering for Vaccine Equity (P4VE) program, funded by the Centers for Disease Control and Prevention (CDC), has addressed racial and ethnic disparities in adult COVID-19 and influenza vaccination. Within P4VE, the Building the Evidence Base for Promising Practices (Promising Practices) project supported national, state, and community organizations in implementing tailored outreach strategies to advance vaccine equity and uptake in their communities.The project provided grants of up to $25,000 to support 18 P4VE-funded organizations across the United States to develop, implement, and evaluate the effectiveness of a promising practice in one of three areas: (1) media-based outreach, (2) community-based outreach, and (3) vaccine events and partnerships. Grantees began their six-month period of performance in August 2022. Target populations served by the selected organizations included Black, Hispanic/Latinx, East and South Asian, Middle Eastern and Arab, and American Indian communities.