Sodium-Glucose Cotransporter-2 Inhibitors in Type 2 Diabetes Mellitus - Streamlined Drug Class Review

This disclaimer and any questions or matters of any nature arising from or relating to the content or use (or misuse) of this document will be governed by and interpreted in accordance with the laws of the Province of Ontario and the laws of Canada applicable therein, and all proceed ings shall be subject to the exclusive jurisdiction of the courts of the Province of Ontario, Canada. [...] The objective of this report is to identify, summarize and critically appraise (if applicable): • The best available evidence regarding the efficacy and harms of SGLT2 inhibitors compared to other antihyperglycemics available in Canada for the treatment of adult patients with type 2 diabetes mellitus. [...] The names and backgrounds of the two specialist members will be shared at the conclusion of the review to discourage attempts to directly lobby the specialists. [...] Assessment of Incoherence The author judged the local incoherence by considering the clinical and statistical significance of the ratio of direct and indirect estimates for each network loop. [...] Assessment of the Certainty of the Evidence The certainty of evidence at the level of the comparison-outcome was assessed following GRADE (Grading of Recommendations Assessment, Development and Evaluation) guidance18.