Current clinical efficacy of chloroquine for the treatment of Plasmodium falciparum infections in urban Dar es Salaam, United Republic of Tanzania.

Research Current clinical efficacy of chloroquine for the treatment of Plasmodium falciparum infections in urban Dar es Salaam, United Republic of Tanzania Z. Premji,1 C. Makwaya,2 & J. N. Minjas3 Reported is the use of a 14-day WHO protocol, which takes into account the clinical, parasitological and haematological responses to antimalarial drugs, to determine the efficacy of chloroquine in the tr [...] Introduction Materials and methods Since the emergence of chloroquine-resistant falci- Study site parum malaria in the United Republic of Tanzania (1) The study was carried out at Temeke district hospital there has been an upward trend in the frequency and during the peak malaria transmission season in 1997 degree of the resistance (2). [...] The hospital serves a population of quine remains the official first-line antimalarial drug about 800 000 people in Temeke district, one of the in the United Republic of Tanzania, while neighbour- three administrative districts within the city of Dar es ing Malawi and Kenya have already replaced Salaam. [...] If the patient showed The children were again seen on day 14, when in one of the following during the follow-up period, addition to the clinical examination and blood slide i.e. [...] The high treatment Haematological response failure rate seen with chloroquine and its low impact on the anaemic status of children call for a change in The mean packed cell volume at enrolment of the official drug policy.