It is worth noting that while the vaccination schedule for the HPV vaccine includes two doses, by working with girls who were unvaccinated before the trial, the SMS reminder and trial more generally focuses only on uptake of the first dose of the HPV vaccine - we do not have data to comment on the impact of the intervention on uptake of the second dose of the vaccine. [...] Whilst it is possible that some of the girls (or their caregivers) could leave the country, or become too unwell to receive the HPV vaccine, during the 62-day trial period, the nature of the intervention and trial (with no way to ‘drop out’ from receiving the one-time intervention), meant that the main risk to the delivery of the intervention as intended arose prior to implementation. [...] Data cleaning steps included the exclusion from analysis of the following cohorts of girls, to ensure that the analysis was performed on the eligible population of interest only: ● Girls who had already received a dose of the HPV vaccine before 16/09/2022 (n=969, of which 193 were in the control group) ○ The reason that there were (contrary to the design of the trial) in fact some girls within the. [...] For the ToT analysis, although excluding this cohort under (a) above does 1) reduce the size of the control group relative to the other groups within the analysis, and 2) imply that girls in the ToT control group are potentially less likely to have sisters than the the girls in the treatment arms, the sample is still sufficiently powered, and the results (and their interpretation) are consistent w. [...] While each of the four versions of the SMS achieved a statistically significant increase in vaccination relative to the control group, version 3 of the SMS reminder (with “reserved for her” framing) was the most effective in encouraging uptake of the HPV vaccine.
- Pages
- 43
- Published in
- United Kingdom
