Leiden mouse that accurately mimics the etiology and pathology of MASH and fibrosis in humans. [...] Translation of the model was verified on the molecular level • Surgical removal of inflamed WAT attenuates NASH by transcriptomics and metabolomics analyses and in a d evelopment in obese mice (Mulder et al., Int J Obes 2016). [...] 2022 | van den Hoek et al., Metabolism 2021 Milk-fat globule membrane Metabolism Arnoldussen et al., Int J Obes 2021 Natural cholesterol lowering compounds Neutrophils Morrison et al., Front Endocrinol 2021 Resmetirom THR-β In preperation Selected references • Gart et al., Translational characterization of the temporal • Morrison et al., Obeticholic acid attenuates fibrosis dynamics of metabolic d. [...] • van Koppen et al., Uncovering a predictive molecular • van den Hoek et al., Diet and exercise reduce pre-existing signature for the onset of NASH related fibrosis in NASH and fibrosis and have additional beneficial effects a translational NASH mouse model. [...] • Mulder et al., Surgical removal of inflamed epididymal • Gart et al., Krill oil treatment increases distinct PUFAs w hite adipose tissue attenuates the development of and oxylipins in adipose tissue and liver and attenuates non-alcoholic steatohepatitis in obesity.
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- Netherlands
