doi: 10.1503/cmaj.221502 Nausea and vomiting of pregnancy are often considered normal and affect most pregnancies, with 1 meta-analysis finding the Key points average reported rate to be 70%.1 The severe end of the clinical spectrum of nausea and vomiting of pregnancy is called hyper- • Diagnosis of hyperemesis gravidarum can be made in the first 16 weeks of pregnancy when a person has nausea and. [...] siderable health care resources, as it is a common reason for hospital admission and emergency department visits in the first • In the absence of curative options, treatments are aimed at symptom reduction and have the potential to improve quality trimester.3,4 In the absence of curative options, treatments are of life and perinatal outcomes, and to reduce the aimed at symptom reduction and have t. [...] The only drug approved (in Canada and the United hyperemesis gravidarum on mood and of limited ability to com- Kingdom) specifically for the treatment of nausea and vomiting of plete activities of daily living, including caring for young pregnancy is the delayed-release formulation of doxylamine suc- children.70 cinate (10 mg) and pyridoxine hydrochloride (10 mg), as this com- A 2015 Cochrane revi. [...] with the combination of increased risk of cleft palate and Clinicians should weigh the risk doxylamine and pyridoxine.50 In heart defects, or whether the of untreated severe another RCT, it was more severity of the indication plays a hyperemesis gravidarum and effective than metoclopramide role, is unclear.21,52,53 small increased risk of for reducing vomiting but congenital abnormalities, in not. [...] Long-term health outcomes of chil- effect and safety of ginger in the treatment of pregnancy-associated nausea dren born to mothers with hyperemesis gravidarum: a systematic review and and vomiting.
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