Authors
Gonçalo Boleto, Silje Reiseter, Anna-Maria Hoffmann-Vold, Adrien Mirouse, Patrice Cacoub, Marco Matucci-Cerinic, Manuel Silvério-António, Joao Eurico Fonseca, Ana Catarina Duarte, Jorge Pestana Lopes, Valeria Riccieri, Alain Lescoat, Erwan Le Tallec, Ivan Castellví Barranco, Jose Luis Tandaipan, Paolo Airó, Masataka Kuwana, Hoda Kavosi, Jérôme Avouac, Yannick Allanore
- Bibliographic Reference
- Gonçalo Boleto, Silje Reiseter, Anna-Maria Hoffmann-Vold, Adrien Mirouse, Patrice Cacoub, et al.. The phenotype of mixed connective tissue disease patients having associated interstitial lung disease. Seminars in Arthritis and Rheumatism, 2023, 63, pp.152258. ⟨10.1016/j.semarthrit.2023.152258⟩. ⟨hal-04244332⟩
- DOI
- https://doi.org/10.1016/j.semarthrit.2023.152258
- HAL Collection
- ['Université de Rennes 1', 'CNRS - Centre national de la recherche scientifique', "Université d'Angers", 'AP-HP', 'SFR Biosit - Biologie et Santé CNRS UMS 3480', 'Publications CHU - Rennes 1', 'Institut de Recherche en Santé, Environnement et Travail', 'TRANSCRIPTION, ENVIRONMENT and CANCER (TREC)', 'NEUROENDOCRINE EFFECTS OF ENDOCRINE DISRUPTORS', "Recherches épidémiologiques sur l'environnement, la reproduction et le développement", "UFR SVE Sciences de la vie et de l'environnement", 'Publications labos UR1 dans HAL-Rennes 1', 'UR1 - publications SDV', 'TEST Université de Rennes CSS', 'Université de Rennes', 'Sorbonne Université', 'Sorbonne Université 01/01/2018', 'Faculté de Santé de Sorbonne Université', 'Médecine - Sorbonne Université', 'Université Paris Cité', 'Université de Paris - Faculté de Santé', 'Sorbonne Université - Texte Intégral', 'Pôle Rennes 1 - Biologie-Santé', 'Alliance Sorbonne Université']
- HAL Identifier
- 4321578
- Institution
- ['Institut National de la Santé et de la Recherche Médicale', 'Université Paris Cité', 'Hôpital Cochin [AP-HP]', 'Oslo University Hospital [Oslo]', 'CHU Pitié-Salpêtrière [AP-HP]', 'Università degli Studi di Firenze = University of Florence', 'Universidade de Lisboa', 'Hospital Garcia de Orta', "Université d'Angers", 'Université de Rennes', 'École des Hautes Études en Santé Publique [EHESP]', 'Structure Fédérative de Recherche en Biologie et Santé de Rennes', 'Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]', 'Hospital de la Santa Creu i Sant Pau', 'Civic Hospital of Brescia', 'Nippon Medical School [Tokyo, Japon]', 'Tehran University of Medical Sciences']
- Laboratory
- ['Institut Cochin', 'Institut de recherche en santé, environnement et travail']
- Published in
- France
Table of Contents
- Submitted on 4 Dec 2023 1
- Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License 1
- HIGHLIGHTS 2
- This is the largest cohort of patients with mixed connective tissue disease 2
- MCTD having associated interstitial lung disease ILD 2
- Upper gastrointestinal involvement and elevated C-reactive protein 5mgL were 2
- History of digital ulceration was identified as an independent major risk factor 2
- The phenotype of mixed connective tissue disease patients having associated interstitial lung disease 3
- Key words 4
- This manuscript includes 4
- Abstract 4
- Correspondence should be addressed to 4
- Competing interests 4
- KEY MESSAGES 5
- This is the largest cohort of patients with mixed connective tissue disease 5
- MCTD having associated interstitial lung disease ILD 5
- Upper gastrointestinal involvement and elevated C-reactive protein 5mgL were 5
- History of digital ulceration was identified as an independent major risk factor 5
- ABSTRACT 6
- Objective 6
- Methods 6
- Results 6
- Conclusion 6
- Funding 6
- INTRODUCTION 7
- PATIENTS AND METHODS 7
- Patients 7
- Ethical considerations 9
- Statistical analysis 9
- RESULTS 10
- Study population and patient characteristics 10
- Table 1 10
- Comparison between MCTD-ILD and MCTD without ILD patients at baseline 10
- Table 1 10
- Table 2 11
- Baseline lung features of MCTD-ILD group 11
- Table 3 11
- Longitudinal analysis 11
- Longitudinal analysis of MCTD-ILD group at 12 months 3 months 12
- Longitudinal analysis of MCTD-ILD group at last follow-up 12
- Table 4 12
- Supplementary Table 1 12
- Supplementary 12
- Figure 1 12
- Supplementary Table 2 12
- DISCUSSION 13
- REFERENCES 16
- Am J Med 16
- Intern Med 16
- Best Practice 17
- Research Clinical Rheumatology 17
- J Autoimmun 17
- Semin Arthritis Rheum 17
- Am J Respir Crit Care Med 17
- Respir Med 17
- Ann Rheum Dis 17
- Ann 17
- Rheum Dis 17
- Ann Rheum Dis 17
- Ann Rheum Dis 17
- J Scleroderma Relat Disord 17
- Ann Rheum Dis 17
- Semin Ultrasound CT MR 17
- Am J Respir Crit Care Med 18
- Medicine Baltimore 18
- Arthritis Rheum 18
- Arthritis Res Ther 18
- J Thorac Imaging 18
- J Comput Assist Tomogr 18
- Rheumatology Oxford 18
- Rheumatology Oxford 18
- The Journal of Rheumatology 18
- Respir Med 18
- Chest 18
- Gastroenterology 18
- Clin Exp Rheumatol 18
- Annals of the Rheumatic Diseases 18
- Arthritis Rheumatology 19
- Arthritis Res Ther 19
- European Respiratory Journal 19
- J Rheumatol 19
- Rheumatology Oxford 19
- Arthritis Care Res Hoboken 19
- Modern Rheumatology 19
- Am J Respir Crit Care Med 19
- Table 3. 24
- MCTD-ILD 24
- Clinical manifestations 24
- HRCT pattern 24
- Lung function tests 24
- Abbreviations 24
- Table 4. 24
- Variables Baseline n150 Follow-up n99 24
- Abbreviations 24
- Declaration of interests 25
- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. 25
- The authors declare the following financial interestspersonal relationships which may be 25
