Evidencesynthesisonprognosticfactors aftercardiopulmonaryresuscitationfor in-hospitalorout-of-hospitalcardiacarrest Reporttothe SwissAcademyofMedicalSciences 30November2018

The present evidence synthesis was commissioned with the aim to review the current evidence on factors that are associated with the long-term prognosis of cardiac arrest after CPR in both the in- hospital and out-of-hospital setting. [...] 2.9 Assessment of review quality We chose an adapted version of the Risk of Bias in Systematic Reviews (ROBIS) tool, for the assessment of the methodological quality of the included systematic reviews. [...] 3.3 Quality of included reviews In the overall assessment of methodological quality, two1,2 of the 21 included reviews had low risk of bias and one18 had unclear risk of bias. [...] BMI 18.5-24.9 110 OR 1.08 (0.53 to 2.17)*** Intra-arrest Cardiac arrest witnessed by bystander 115 OR 0.34 (0.07 to 1.66) to 4.42 (1.81 to 10.80)**** Cardiac arrest witnessed by EMS 115 OR 1.65 (0.63 to 4.34) to 6.04 (4.12 to 8.85)**** Bystander CPR 115 OR 0.98 (0.29 to 3.35) to 5.01 (2.57 to 9.78)**** VF/VT as presenting cardiac rhythm vs. [...] 115 OR 2.91 (1.10 to 7.66) to other rhythms 20.62 (12.61 to 33.72)**** Asystole as presenting cardiac rhythm 115 OR 0.10 (0.03 to 0.31) to 0.33 (0.19 to 0.57)**** Gasping 124** RR 3.525 (3.03 to 4.10) Post-arrest Return of spontaneous circulation 115 OR 20.96 (7.43 to 59.13) to 99.84 (14.30 to 696.89)**** Conversion to spontaneous shockable 19 unadjusted OR 1.38 (0.66 to rhythm 2.89) Transport tim.