Tight junction stabilization prevents HepaRG cell death in drug-induced intrahepatic

These results suggest that the drastic change in the was no change in the distribution of A in the culture without size of the BC surface resulted in the disruption of TJ in HepaRG ENT until t=48 h (Fig. [...] In the culture with ENT, dilation of surrounded the BC, as observed in the culture without drugs, in spite BC pressed the nuclei of neighboring cells, and the morphology of its BC dilation (Fig. [...] From these results, it is clear that the dynamic behavior of the expanded size of BC, keeping the localization of ZO-1 in the BC resulted in the alteration of hepatic function and BC structure. [...] The exposure of HepaRG cells to FOR in the culture with ENTwas found to suppress the alteration of the BC size through the robust BC structure, resulting in the inhibition of apoptosis. [...] These reports suggest that the V Apoptosis and Necrosis Assay, the apoptotic cells were measured by the maintenance of TJ via the cAMP-Epac-Rap1-MEK signaling exposure of phosphatidylserine on the outer leaflet of the cell membrane pathway allows the inhibition of apoptosis in cells cultured with during the apoptotic process, and assay signals were detected using a ENT and TAU or FOR.