GUIDANCE NOTE 7 - Substances of high concern EMCDDA operating guidelines for the European Union Early Warning

Purpose The purpose of this document is to provide a list of substances of high concern monitored by the EMCDDA and the rationale for reporting events involving the identification of such substances. [...] What is a substance of high concern? A substance of high concern is any substance that is not a new psychoactive substance or controlled drug but that is toxic or otherwise hazardous and poses a high risk of acute or chronic poisoning or any other type of serious adverse event. [...] The identification of a substance of high concern is subject to expedited reporting by the Reitox National Focal Points when: • It is identified with or sold as a new psychoactive substance; or, • it is identified with or sold as controlled drug; or • there is reasonable probability that it is linked in some way to the NPS market or the controlled drug market. [...] Substances are added to the list by the EMCDDA based on reports of identifications involving serious adverse events reported either by the Member States or from any other information at the disposal of the EMCDDA (such as the scientific and medical literature). [...] Changes since last version • 4,4'-Methylenedianiline added to the list of substances of high concern 8 Guidance Note 7: Substances of high concern EMCDDA operating guidelines for the European Union Early Warning System on new psychoactive substances 1.