The purpose of the IOMC is to promote co-ordination of the policies and activities pursued by the Participating Organisations, jointly or separately, to achieve the sound management of chemicals in relation to human health and the environment. [...] During 14 14 the test period, 4-5 μc of CO2 was exhaled, and the distribution of C was 11.9-12.3 mμc/mmole in the carcass and 43.6-46.0 mμc/mmole in the liver. [...] An increase was reported in the incidence of stones in the kidney, ureter and bladder in rats in the high dose group. [...] Non-cancer effects observed were an increased incidence of basophilic cell foci in the liver of females at 2000 and 6000 ppm (incidences of 1/50, 1/50, 16/50, 14/50, respectively), and in the kidneys, increased incidences of necrotic desquamation of urothelium in the renal pelvis of males and females (significant at 6000 ppm only), as well as mineralization in the inner stripe of the outer medulla. [...] This is supported by the findings that bladder tumours occurred in close association with calculus formation and haematuria, and also supported by the observed sex differences in structure and composition of calculi and in occurrence of haematuria, which was absent in females.
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