Multiple organ system toxicity of glyphosate and Roundup Bioflo (MON 52276) at regulatory relevant doses

Use of shotgun metagenomics and metabolomics to evaluate the impact of glyphosate or Roundup MON 52276 on the gut microbiota and serum metabolome of Sprague-Dawley rats. [...] • Three glyphosate Glyphosate and RangerPro and Roundup Bioflow (MON equivalent doses of 52276) reduced colonisation resistance and allowed Roundup Bioflow opportunistic (potentially pathogenic) fungi to grow in and RangerPro the gut. [...] 131: 37001, 2023 “Childhood exposure to glyphosate and AMPA may increase risk of liver and cardiometabolic disorders in early adulthood, which could lead to more serious diseases later in life.” Non-standard tests were most revealing • Roundup MON 52276 altered the expression of 96 genes in the liver linked to oxidative stress and DNA damage, as well as disruption of circadian rhythms ("body clock. [...] • Core gene expression changes reflective of oxidative stress and DNA damage were the same in Roundup and glyphosate-treated animals; thus due to glyphosate and not the co-formulants in the Roundup MON 52276. [...] Regulatory “safe” doses of glyphosate and Roundup shown to be unreliable • All doses of glyphosate and Roundup MON 52276 tested caused some adverse effects; current EU glyphosate / Roundup NOAEL and ADI are incorrect.